Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
42 results
JMIR formative research, Volume 8, 15 3 2024, Pages e38803 Use Intention and User Expectations of Human-Supported and Self-Help eHealth Interventions: Internet-Based Randomized Controlled Trial. Cohen Rodrigues TR, Reijnders T, Breeman LD, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AW
Background: Self-help eHealth interventions provide automated support to change health behaviors without any further human assistance. The main advantage of self-help eHealth interventions is that they have the potential to lower the workload of health care professionals. However, one disadvantage is that they generally have a lower uptake. Possibly, the absence of a relationship with a health care professional (referred to as the working alliance) could lead to negative expectations that hinder... Abstract
Internet interventions, Volume 35, 8 2 2024, Pages 100726 Human cues in eHealth to promote lifestyle change: An experimental field study to examine adherence to self-help interventions. Cohen Rodrigues TR, de Buisonjé DR, Reijnders T, Santhanam P, Kowatsch T, Breeman LD, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM, BENEFIT consortium
eHealth lifestyle interventions without human support (self-help interventions) are generally less effective, as they suffer from lower adherence levels. To solve this, we investigated whether (1) using a text-based conversational agent (TCA) and applying human cues contribute to a working alliance with the TCA, and whether (2) adding human cues and establishing a positive working alliance increase intervention adherence. Participants (N = 121) followed a TCA-supported app-based physical activit... Abstract
Frontiers in nutrition, Volume 10, 22 4 2023, Pages 1178134 Identifying barriers and facilitators to adopting healthier dietary choices in clinical care: a cross-sectional observational study. de Frel DL, Wicks H, Bakk Z, van Keulen N, Atsma DE, Janssen VR
Background and aims: Adopting healthier diets can drastically improve societal health. Our environment plays a crucial role in daily dietary choices and hospitals in particular can stimulate patients to adopt healthier eating habits. Unfortunately, no robust clinically applicable cuing tools exist to help guide in-hospital dietary interventions. The purpose of this study was to identify patient-related barriers and facilitators to adopting healthier dietary choices. Methods and results: This cro... Abstract
BMC health services research, Volume 23, Issue 1, 21 3 2023, Pages 1455 An iterative approach to developing a multifaceted implementation strategy for a complex eHealth intervention within clinical practice. IJzerman RVH, van der Vaart R, Breeman LD, Arkenbout K, Keesman M, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Background: The number of complex eHealth interventions has increased considerably. Despite available implementation theory outlining well-designed strategies, implementing complex interventions within practice proves challenging and often does not lead to sustainable use. To improve sustainability, theory and practice should be addressed during the development of an implementation strategy. By subsequently transparently reporting the executed theory-based steps and their corresponding practice... Abstract
Journal of medical Internet research, Volume 25, 4 1 2023, Pages e48461 Guide Development for eHealth Interventions Targeting People With a Low Socioeconomic Position: Participatory Design Approach. Faber JS, Al-Dhahir I, Kraal JJ, Breeman LD, van den Berg-Emons RJG, Reijnders T, van Dijk S, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM
Background: People with a low socioeconomic position (SEP) are less likely to benefit from eHealth interventions, exacerbating social health inequalities. Professionals developing eHealth interventions for this group face numerous challenges. A comprehensive guide to support these professionals in their work could mitigate these inequalities. Objective: We aimed to develop a web-based guide to support professionals in the development, adaptation, evaluation, and implementation of eHealth interve... Abstract
Cited 1 times since 2023 (2.1 per year) source: EuropePMC
The Journal of investigative dermatology, 25 4 2023, Pages S0022-202X(23)03115-9 Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations. Langbroek GB, Stor MLE, Janssen V, de Haan A, Horbach SER, Graupera M, van Noesel CJM, van der Horst CMAM, Wolkerstorfer A, Huveneers S
Capillary malformations (CM) (port-wine stains) are congenital skin lesions that are characterized by dilated capillaries and postcapillary venules. CMs are caused by altered functioning of the vascular endothelium. Somatic genetic mutations have predominantly been identified in the endothelial cells of CMs, providing an opportunity for the development of targeted therapies. However, there is currently limited in-depth mechanistic insight into the pathophysiology and a lack of preclinical resear... Abstract
Cited 1 times since 2023 (1.9 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 32, Issue 1, 9 2 2023, Pages 38-44 Brief lifestyle advice in cardiac care: an experimental study on message source and framing. IJzerman RVH, van der Vaart R, Breeman LD, van den Broek I, Keesman M, Kraaijenhagen RA, Reijnders T, Weerts M, Evers AWM, Scholte Op Reimer WJM, Janssen VR, BENEFIT consortium
Objective: Communicating risk information and offering lifestyle advice are important goals in cardiac rehabilitation. However, the most effective way and the most effective source to communicate this information are not yet known. Therefore, we examined the effect of source (cardiologist, physiotherapist) and framing (gain, loss) of brief lifestyle advice on patients' intention-to-change-lifestyle. Methods: In an online experimental study, 636 cardiac patients (40% female, 67 (10) yrs.) we... Abstract
Social science & medicine (1982), Volume 338, 26 4 2023, Pages 116348 Making sense of a myocardial infarction in relation to changing lifestyle in the five months following the event: An interpretative phenomenological analysis. Brust M, Gebhardt WA, van Bruggen S, Janssen V, Numans ME, Kiefte-de Jong JC
Objective: Previous research has shown that experiencing an acute cardiac event, such as a myocardial infarction (MI), can lead to lifestyle changes. This study aimed to explore the potential of a MI as a 'teachable moment' (TM) for positive lifestyle changes and to identify psychosocial sensemaking processes that facilitate or hinder the presence of a TM. Method: We conducted semi-structured interviews with 14 patients who suffered their first MI and were hospitalized in a larger Dutc... Abstract
Cited 1 times since 2023 (1.7 per year) source: EuropePMC
Psychosomatic medicine, Volume 85, Issue 9, 9 2 2023, Pages 795-804 Effectiveness of Human-Supported and Self-Help eHealth Lifestyle Interventions for Patients With Cardiometabolic Risk Factors: A Meta-Analysis. Cohen Rodrigues TR, Breeman LD, Kinik A, Reijnders T, Dusseldorp E, Janssen VR, Kraaijenhagen RA, Atsma DE, Evers AWM, BENEFIT consortium
Objective: eHealth is a useful tool to deliver lifestyle interventions for patients with cardiometabolic diseases. However, there are inconsistent findings about whether these eHealth interventions should be supported by a human professional, or whether self-help interventions are equally effective. Methods: Databases were searched between January 1995 and October 2021 for randomized controlled trials on cardiometabolic diseases (cardiovascular disease, chronic kidney disease, type 1 and 2 diabe... Abstract
Psychology of sport and exercise, Volume 70, 9 2 2023, Pages 102532 Less stick more carrot? Increasing the uptake of deposit contract financial incentives for physical activity: A randomized controlled trial. de Buisonjé DR, Reijnders T, Cohen Rodrigues TR, Santhanam P, Kowatsch T, Breeman LD, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM
Background: Financial incentives are a promising tool to help people increase their physical activity, but they are expensive to provide. Deposit contracts are a type of financial incentive in which participants pledge their own money. However, low uptake is a crucial obstacle to the large-scale implementation of deposit contracts. Therefore, we investigated whether (1) matching the deposit 1:1 (doubling what is deposited) and (2) allowing for customizable deposit amounts increased the uptake an... Abstract
Cited 1 times since 2023 (1.2 per year) source: EuropePMC
International journal of medical informatics, Volume 177, 22 4 2023, Pages 105160 An overview of facilitators and barriers in the development of eHealth interventions for people of low socioeconomic position: A Delphi study. Al-Dhahir I, Breeman LD, Faber JS, Reijnders T, van den Berg-Emons HJG, van der Vaart R, Janssen VR, Kraaijenhagen R, Visch VT, Chavannes NH, Evers AWM, Medical Delta program eHealth and self-management
Objective: eHealth interventions can improve the health outcomes of people with a low socioeconomic position (SEP) by promoting healthy lifestyle behaviours. However, developing and implementing these interventions among the target group can be challenging for professionals. To facilitate the uptake of effective interventions, this study aimed to identify the barriers and facilitators anticipated or experienced by professionals in the development, reach, adherence, implementation and evaluation... Abstract
Internet interventions, Volume 32, 27 4 2023, Pages 100626 Corrigendum to 'Put your money where your feet are: The real-world effects of StepBet gamified deposit contracts for physical activity' [Internet Interv., volume 31, March 2023, 100610]. de Buisonjé DR, Brosig F, Breeman LD, Bloom EL, Reijnders T, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM
[This corrects the article DOI: 10.1016/j.invent.2023.100610.]. Abstract
Cited 1 times since 2023 (0.9 per year) source: EuropePMC
JMIR cardio, Volume 7, 24 4 2023, Pages e43781 Implementation and User Evaluation of an eHealth Technology Platform Supporting Patients With Cardiovascular Disease in Managing Their Health After a Cardiac Event: Mixed Methods Study. Bente BE, Wentzel J, Schepers C, Breeman LD, Janssen VR, Pieterse ME, Evers AWM, van Gemert-Pijnen L
Background: eHealth technology can help patients with cardiovascular disease adopt and maintain a healthy lifestyle by supporting self-management and offering guidance, coaching, and tailored information. However, to support patients over time, eHealth needs to blend in with their needs, treatment, and daily lives. Just as needs can differ between patients, needs can change within patients over time. To better adapt technology features to patients' needs, it is necessary to account for thes... Abstract
Internet interventions, Volume 31, 26 4 2023, Pages 100610 Put your money where your feet are: The real-world effects of StepBet gamified deposit contracts for physical activity. de Buisonjé DR, Brosig F, Breeman LD, Bloom EL, Reijnders T, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM
Background: Gamification and deposit contracts (a financial incentive in which participants pledge their own money) can enhance effectiveness of mobile behavior change interventions. However, to assess their potential for improving population health, research should investigate implementation of gamified deposit contracts outside the research setting. Therefore, we analyzed data from StepBet, a smartphone application originally developed by WayBetter, Inc. Objective: To perform a naturalistic ev... Abstract
Cited 1 times since 2023 (0.7 per year) source: EuropePMC
Cellular signalling, Volume 104, 5 1 2023, Pages 110587 Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex. Clemente-Olivo MP, Hernández-Quiles M, Sparrius R, van der Stoel MM, Janssen V, Habibe JJ, van den Burg J, Jongejan A, Alcaraz-Sobrevals P, van Es R, Vos H, Kalkhoven E, de Vries CJM
The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore, we investigated the role of FHL2 in adipocyte differentiation. For these studies pre-adipocytes isolated from mouse adipose tissue and the 3T3-L1 (pre)adipocyte cell line were applied. We performed FH... Abstract
Clinical nutrition (Edinburgh, Scotland), Volume 42, Issue 1, 17 3 2022, Pages 18-21 An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities. de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE
Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 33, Issue 1, 8 2 2022, Pages 56-64 Development, internal reliability and preliminary construct validity of the Dutch Dietary Intention Evaluation Tool for In-patients (DIETI). de Frel DL, Wicks H, Bakk Z, van Keulen N, van Adrichem V, van Tussenbroek N, Atsma PDE, Janssen VR
Background and aims: Diet is important in prevention and management of non-communicable disease and in particular, cardiovascular disease. Recently, more hospitals gear towards healthier dietary policies, however, a tool to assess the effect of these interventions in patient populations is currently lacking. The Theory of Planned Behavior (TPB) is generally used to assess health-related behavior and offers a framework for development of questionnaires. In this study, we aim to evaluate the relia... Abstract
Cited 2 times since 2022 (1.2 per year) source: EuropePMC
Journal of medical Internet research, Volume 24, Issue 10, 6 1 2022, Pages e38339 Investigating Rewards and Deposit Contract Financial Incentives for Physical Activity Behavior Change Using a Smartphone App: Randomized Controlled Trial. de Buisonjé DR, Reijnders T, Cohen Rodrigues TR, Prabhakaran S, Kowatsch T, Lipman SA, Bijmolt THA, Breeman LD, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM
Background: Financial incentive interventions for improving physical activity have proven to be effective but costly. Deposit contracts (in which participants pledge their own money) could be an affordable alternative. In addition, deposit contracts may have superior effects by exploiting the power of loss aversion. Previous research has often operationalized deposit contracts through loss framing a financial reward (without requiring a deposit) to mimic the feelings of loss involved in a deposi... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
Journal of cardiopulmonary rehabilitation and prevention, Volume 42, Issue 6, 24 4 2022, Pages E99-E100 Know Your Numbers: Patient and Physician Disparity in Cardiovascular Risk Perception After an Acute Coronary Syndrome. Ter Hoeve N, Jorstad HT, Sunamura M, Janssen VR, Scholte Op Reimer WJM, Snaterse M
Cited 7 times since 2022 (4 per year) source: EuropePMC
Journal of medical Internet research, Volume 24, Issue 8, 24 4 2022, Pages e34229 The Barriers and Facilitators of eHealth-Based Lifestyle Intervention Programs for People With a Low Socioeconomic Status: Scoping Review. Al-Dhahir I, Reijnders T, Faber JS, van den Berg-Emons RJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM
Background: Promoting health behaviors and preventing chronic diseases through a healthy lifestyle among those with a low socioeconomic status (SES) remain major challenges. eHealth interventions are a promising approach to change unhealthy behaviors in this target group. Objective: This review aims to identify key components, barriers, and facilitators in the development, reach, use, evaluation, and implementation of eHealth lifestyle interventions for people with a low SES. This review provide... Abstract